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Citation: CAO Ling-Hua, ZHOU Chuan-Jian. Synthesis of N,N'-Di(glycosylthioureylene) arylthiophosphonic diamides[J]. Chinese Journal of Applied Chemistry, ;2004, 21(3): 239-242. shu

Synthesis of N,N'-Di(glycosylthioureylene) arylthiophosphonic diamides

CAO Ling-Hua ^a,b,, ,
ZHOU Chuan-Jian ^a,b

1.
a Department of Chemistry, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046;
2.
b State Key Laboratory of Elemento-Organic Chmistry, Nankai University, Tianjin

Corresponding author: CAO Ling-Hua,
Received Date: 24 February 2003
Available Online: 19 November 2003
Fund Project: 国家自然科学基金(29962002) (29962002)

Reactions of dichloroarylphosphine(1a~1c) with PSCl₃ gave corresponding arylthiophosphonic dichlorides(2a~2c), which after hydrazinolyzation gave arylthiophosphonic dihydrazides(3a~3c). Reactions of 3a~3c with glycosyl isothiocyanates(4a~4e) in benzene gave corresponding N,N'-di(glycosylthioureylene) arylthiophosphonic diamides(5a~5e,6a~6e,7a~7e). Their structures were confirmed by IR, ¹H NMR, ³¹P NMR, MS and elemental analysis. The glycosyl isothiocyanates 4a~4e were prepared by the reaction of α-D-glycosyl bromides with Pb(SCN)₂. The biological activities of the representative compounds have been examined.
- N,N'-di(glycosylthioureylene)arylthiophosphonic diamide,
- synthesis,
- glycosyl isothiocyanate,
- thiophosphonic dihydrazide,
- biological activity
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