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Citation: YANG Yuan-Yuan, ZHOU Guo-Quan, CHEN Xin-Zhi. An Improved Synthesis of 4-Aminopyridine[J]. Chinese Journal of Applied Chemistry, ;2004, 21(5): 530-531. shu

An Improved Synthesis of 4-Aminopyridine

1.
College of Material Science and Chemical Engineering, Zhejiang University, Hangzhou 310027

Corresponding author: CHEN Xin-Zhi,
Received Date: 6 June 2003
Available Online: 31 December 2003

4-Cyanopyridine was at first catalytically hydrolyzed to give isonicotinamide in the presence of Mg-Fe oxides with yield 92%. 4-Aminopyridine was obtained from isonicotinamide in yield of 83%~85% by Hofmann reaction using iodo-benzene as catalyst. All of the reaction were monitored by TLC and the products were confirmed by IR, NMR and melting point determination.
- aminopyridine,
- cyanopyridine,
- Hofmann reaction,
- hydrolysis
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