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Citation: HU Guo-Qiang, XING Yong, ZHANG Zhong-Quan, CHENG Bai-Quan, XU Qi-Tai, HUANG Wen-Long, ZHANG Hui-Bin, HUANG Sheng-Tang. Synthesis and Antibacterial Activity of Bisoxadiazole Sulfurether/Sulfone Derivatives[J]. Chinese Journal of Applied Chemistry, ;2004, 21(6): 561-565. shu

Synthesis and Antibacterial Activity of Bisoxadiazole Sulfurether/Sulfone Derivatives

1.
a Medical College of Henan University, Kaifeng 475004;
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b China Pharmaceutical University, Nanjing

Corresponding author: HU Guo-Qiang,
Received Date: 20 August 2003
Available Online: 18 December 2003
Fund Project: 国家自然科学基金(30070861) (30070861)河南大学科研基金(XK02041)资助项目 (XK02041)

Twenty 1,3,4-oxadiazole sulfurethers(3a~3j) and corresponding sulfone derivatives(4a~4j) were synthesized via condensation of 1,3,4-oxadiazole chloromethane(1) with the corresponding 1,3,4-oxadiazole thiols(2a~2j) followed by oxidation with 30% H₂O₂ in the presence of catalyst Na₂WO₄, and their structures were confirmed by IR, ¹H NMR, MS and elemental analysis. Among the compounds synthesized, the sulfurether compounds (3b) and (3h) exhibited considerably strong inhibiting activity to Staphylococcus aureus and Proteus vulgaris in dosage of 1.0×10^-4(mass fraction), the sulfone compounds 4b, 4c, 4d and 4f exhibited mediumly inhibiting activity to Escherichia.coli, whereas the other compounds showed weak or even no antibacterial activity.
- oxadiazole,
- sulfur ether,
- sulfone,
- antibacterial activity
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