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Citation: XU Qun, HOU Zhen-Zhong, ZHANG Shi-Jie, PENG Qi, REN Xian-Wen. Application of Supercritical CO₂ in Preparation of Salicylic Acid Poly(ε-caprolactone) Controlled Releasing System[J]. Chinese Journal of Applied Chemistry, ;2004, 21(7): 751-753. shu

Application of Supercritical CO₂ in Preparation of Salicylic Acid Poly(ε-caprolactone) Controlled Releasing System

1.
College of Materials Engineering, Zhengzhou University, Zhengzhou 450052

Corresponding author: XU Qun,
Received Date: 25 August 2003
Available Online: 18 January 2004

Salicylic acid as a drug carrying agent was intercalated into microporous poly (ε-caprolactone)(PCL) and PCL resin particles using supercritical CO₂ as solvent.The drug releasing currves in 95% ethanol solution for open-hole PCL and close-hole PCL particles have been obtained and the releasing half-life (t_1/2) for both systems were calculated to be 35 h and 57 h,respectively.The latter appears more preferable.
- supercritical CO₂,
- salicylic acid,
- poly(ε-caprolactone),
- drug releasing
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沈阳化工大学材料科学与工程学院沈阳 110142

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Application of Supercritical CO2 in Preparation of Salicylic Acid Poly(ε-caprolactone) Controlled Releasing System

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通讯作者: 陈斌, bchen63@163.com

Application of Supercritical CO₂ in Preparation of Salicylic Acid Poly(ε-caprolactone) Controlled Releasing System