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Citation: WU Zheng-Cui, LI Qing-Hai, FANG Xiang, SHEN Liang-Jun. Synthesis of Amphiphilic Macromolecular Prodrugs Anchored with Probenecid[J]. Chinese Journal of Applied Chemistry, ;2004, 21(12): 1257-1260. shu

Synthesis of Amphiphilic Macromolecular Prodrugs Anchored with Probenecid

1.
a College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000;
2.
b Department of Biochemistry Engineering, Anhui University of Technology and Science, Wuhu

Corresponding author: WU Zheng-Cui, FANG Xiang,
Received Date: 31 December 2003
Available Online: 30 April 2004
Fund Project: 安徽省教育厅自然科学基金(2003kj147) (2003kj147)安徽工程科技学院青年科研基金(2002YQ004)资助项目 (2002YQ004)

A nonsteroidal antiinflammatory drug, probenecid, was covalently linked with 2-hydroxyethyl methacrylate(HEMA) through esterification reaction. The drug-linked HEMA(abbreviated as HP) was copolymerized with polyoxyethylene macromers(PEO-MA) to obtain macromolecular prodrugs using azobisisobutyronitrile(AIBN) as an initiator. The polymer was characterized with IR, ¹H NMR and GPC. The effect of initiator amount and the ratio of drug to monomer were discussed. Increasing the amount of AIBN decreased the molecular weight of the copolymer. Increasing HP content in monomers increased probenecid content in the copolymer.
- probenecid,
- amphiphilic copolymer,
- macromolecular prodrug
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