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Citation: FANG Xiang, WU Zheng-Cui, WANG Shao-Wu, WU Yong-Ming. Syntheses and Characterization of 2-Fluoroindolizine Derivatives[J]. Chinese Journal of Applied Chemistry, ;2005, 22(1): 75-78. shu

Syntheses and Characterization of 2-Fluoroindolizine Derivatives

1.
a Institue of Organic Chemistry, School of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000;
2.
b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai

Corresponding author: FANG Xiang, WANG Shao-Wu,
Received Date: 22 February 2004
Available Online: 13 July 2004
Fund Project:

2-Fluoroindolizines and 2-fluoro-benzo[d]indolizines 4 were synthesized in yields of 50%~70% via a 1,3-dipolar reaction of fluorinated vinyl tosylate 2 with N-ylides of pyridinium or isoquinolinium for 24 h in the presence of K₂CO₃ and Et₃N in DMF. Their structures were confirmed by ¹H NMR, ¹⁹F NMR, IR, MS and elemental analyses. A reaction mechanism is proposed.
- dipolar reaction,
- fluorinated vinyl tosylate,
- fluoroindolizine,
- mechanism
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