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Citation: WANG Chao-Jie, WANG Yu-Xia, ZHAO Jin, SUN Jian. Synthesis and Biological Evaluation of the Amidated Solanesyl Derivatives[J]. Chinese Journal of Applied Chemistry, ;2005, 22(1): 50-54. shu

Synthesis and Biological Evaluation of the Amidated Solanesyl Derivatives

1.
He'nan Provincial Key Laboratory of Specialty Functional Materials, He'nan University, Kaifeng 475001

Corresponding author: WANG Chao-Jie,
Received Date: 28 February 2004
Available Online: 26 June 2004
Fund Project: 河南省科技厅(0323024000,0311020900,0423031800) (0323024000,0311020900,0423031800)

Eight solanesyl derivatives including N-solanesylamides(5a~5d) and N-acyl-N'-solanesylpiperazines(6a~6d) were synthesized with solanesol as starting material and four commercial drugs as the sources of acyl groups. All the products were characterized by ¹H NMR, IR, MS and elemental analyses. The inhibition activities of 5a~5d and 6a~6d to KB, Bel-7402, HCT-8 cells were biologically evaluated in vitro, the results show these compounds only have poor anti-tumor activity.
- N-solanesylamide,
- N-acyl-N'-solanesylpiperazine,
- synthesis,
- bioactivity
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