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Citation: HU Ai-Xi, WU Hong-Yan, CHEN Ke, YANG Lin-Tao, ZHOU Bing. Synthesis of 2-Aryl-3,5,5-trimethyl-2-morpholinols hydrochloride[J]. Chinese Journal of Applied Chemistry, ;2005, 22(3): 343-345. shu

Synthesis of 2-Aryl-3,5,5-trimethyl-2-morpholinols hydrochloride

1.
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082

Corresponding author: HU Ai-Xi,
Received Date: 29 June 2004
Available Online: 29 October 2004
Fund Project: 高等学校博士学科点专项科研基金(20040532002) (20040532002)湖南省科技计划(04SK30533)资助项目 (04SK30533)

2-Aryl-3,5,5-trimethyl-2-morpholinols were synthesized from the reactions of 2-methyl-2-aminopropanol with 2-bromopropiophenone,2-bromo-3'-chlorop ropiophenone,2-bromo-4'-benzyloxypropio-phenone or 6-methoxy-2-(2-bromopropionyl) naphthalene for 1 h in N-methylpyrrolidone at 35℃.The 2-aryl-3,5,5-trimethyl-2-morpholinols were then reacted with hydrochlo ride in Et₂^O to give the corresponding hydrochloride salts with yields of 84.9% 86.4%,respectively.The structures of 2-aryl-3,5,5-trimethyl-2-morpholinol hydrochlorides were confirmed by mean of IR,¹H NMR,MS spectral data.
- aryltrimethylmorpholinol hydrochloride,
- methylaminopropanol,
- amination
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