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Citation: LU Ling-Bin, HUANG Ke-Long. Preparation of Biodegradable Aliphatic Poly (propylene-co-γ-butyrolactone carbonate) Microcapsules[J]. Chinese Journal of Applied Chemistry, ;2005, 22(3): 250-254. shu

Preparation of Biodegradable Aliphatic Poly (propylene-co-γ-butyrolactone carbonate) Microcapsules

LU Ling-Bin ,
HUANG Ke-Long ^,

1.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083

Corresponding author: HUANG Ke-Long,
Received Date: 12 June 2004
Available Online: 28 August 2004
Fund Project: 国家"八六三"资助项目(2001AA218011) (2001AA218011)

Poly (propylene-co-γ-butyrolactone carbonate) PPCG was synthesized from carbon dioxide,1,2-propylene oxide (PO) and γ-butyrolactone (GBL).The PPCG-dextrose microcapsules were prepared by the diphase emulsion method with gelatin as stabilizer.The structure of the copolymer was characterized by FT IR,¹H NMR and ¹³C NMR.The PPCG was found to be more degradable than polyethylene carbonate (PPC) and could be used in fabrication of microcapsules for long-term drug-releasing technique.The SEM photos indicate that the micro capsules have a smooth and spherical surface sized between 2~2.5 μm.The influences of V(PPCG):V(dextrose),gelatin concentration and preparation process on microcapsules size,drug loading and encapsulation efficiency were studied.When V(PPCG):V(dextrose) is 1:2,ω(gelatin)=0.2%,the first stirring rate 500 r/min,the second stirring rate 400 r/min and stirring time 6 h,the resulting microcapsules have drug loading of 36.7%,encapsulation efficiency of 84.6% and smaller particle size.
- poly (propylene-co-γ-butyrolactone carbonate),
- γ-butyrolactone,
- biodegradable microcapsule
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