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Citation: CAO Song, SONG Gong-Hua, QU Yu-Cheng, WEI Na, LU De-Li, HUANG Qing-Chun. Synthesis and Biological Activity of 5-(3'-Aryl-2'-oxo-5'-oxazolidinylmethoxy)-3(2H) pyridazinones[J]. Chinese Journal of Applied Chemistry, ;2005, 22(4): 448-450. shu

Synthesis and Biological Activity of 5-(3'-Aryl-2'-oxo-5'-oxazolidinylmethoxy)-3(2H) pyridazinones

1.
Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, Shanghai 200237

Corresponding author: CAO Song,
Received Date: 28 June 2004
Available Online: 15 September 2004
Fund Project: "九七三"国家重点基础研究发展规划项目(2003CB114405) (2003CB114405)上海市科委攻关项目资助(034319250) (034319250)

Seven 2-tert-butyl-4-chloro-5-(3'-aryl-2'-oxo-5'-oxazolidinylmethoxy)-3(2H) pyridazinones were synthesized via the reaction of aryl isocyanates and 2-tert-butyl-4-chloro-5-(2,3-epoxypropyloxy)-3(2H)(pyridazinones) prepared by the reaction of 2-tert-butyl-4-chloro-5-hydroxy-3(2H) pyridazinones with epichlorohydrin.The structures of the title compounds were confirmed by ¹H NMR,HR MS and IR.The bioassay tests showed the inhibition of compound 2b and that of compound 2c against Colletotrichum lagenarium under 500 mg/L were 33% and 50%,respectively.
- aryloxooxazolidinylmethoxypyridazinone,
- synthesis,
- biological activity
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