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Citation: LIU Shou-Xin, FENG Xiao, ZHEN Xiao-Li, TIAN Xia. A Novel Semi-synthesis Method for Demecolcine[J]. Chinese Journal of Applied Chemistry, ;2005, 22(5): 569-571. shu

A Novel Semi-synthesis Method for Demecolcine

LIU Shou-Xin ^a,b,, ,
FENG Xiao ^a ,
ZHEN Xiao-Li ^b ,
TIAN Xia ^b

1.
a College of Environmental and Chemical Engineering, Xi'an Jiaotong University, Xi'an 710049;
2.
b College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang

Corresponding author: LIU Shou-Xin,
Received Date: 18 July 2004
Available Online: 4 September 2004

Demecolcine was synthesized from colchicine in two steps.The methylation of colchicine with iodomethane was carried out in a THF solution of potassium t-butoxide at -20℃ for 4 h.The product was isolated on a silica gel flash column with a yield of over 78%.N-Methylcolchicine was then hydrolyzed in i-propanol and aqueous solution of sodium hydroxide under refluxing temperature to give demecolcine.The overall yield was 69%.The structures of the two products were confirmed by IR and ¹H NMR.
- demecolcine,
- colchicine,
- semi-synthesis
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