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Citation: HU Bing-Cheng, LÜ Chun-Xu. Synthesis of 3-Methyl-3-acetyl-4-carboethoxy-cyclohexanone[J]. Chinese Journal of Applied Chemistry, ;2005, 22(6): 669-672. shu

Synthesis of 3-Methyl-3-acetyl-4-carboethoxy-cyclohexanone

HU Bing-Cheng ^, ,
LÜ Chun-Xu

1.
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094

Corresponding author: HU Bing-Cheng,
Received Date: 29 August 2004
Available Online: 28 October 2004

Methylacetylcarboethoxycyclohexanone was synthesized via nitro-reduction from methylnitroethylcarboethoxycyclohexanone,which was produced from methylcarboethoxycyclohexenone and nitroethane by Michael addition.The total yield of the two reactions reached about 42%.The effect of the catalyst on the two reactions was studied.The results show that the optimum catalysts for the Michael addition and the nitro-reduction were tetrabutylammoniumfloride and titanium trichloride,and the yields of the addition product and the reduction product were 54% and 78%,respectively.The structures of the compounds were charac-terized by elemental analysis,IR,¹H NMR,and MS.
- methylacetylcarboethoxycyclohexanone,
- methylcarboethoxycyclohexenone,
- nitroethane,
- methylnitro-ethylcarboethoxycyclohexanone,
- tetrabutylammoniumfloride,
- titanium trichloride
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