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Citation: WANG Hua-Lin, FANG Da-Qing, SHI Tie-Jun, ZAI Lin-Feng, WANG Ji-Zhi. Synthesis of Poly (D,L-Lactic Acid) and Its Degradation in Saline Solution[J]. Chinese Journal of Applied Chemistry, ;2005, 22(6): 657-660. shu

Synthesis of Poly (D,L-Lactic Acid) and Its Degradation in Saline Solution

1.
a School of Chemical Technology, Hefei University of Technology, Hefei 230009;
2.
b MOE Key Laboratory of Bioprocess, Hefei University of Technology, Hefei 230009

Corresponding author: WANG Hua-Lin,
Received Date: 28 June 2004
Available Online: 10 October 2004
Fund Project: 安徽省自然科学基金资助项目(01044803) (01044803)

Using stannous octoate (ZnOct₂) as the catalyst,poly (D,L-lactic acid)(PDLLA) was synthesized.The effects of catalyst amount,polymerization temperature and time on the molecular weight of PDLLA were studied.The optimal conditions were as follows:mass fraction of ZnOct₂ 0.5%,reaction temperature 170℃,reaction time 7 h.The degradation of PDLLA in normal saline was explored,and the degradation products were characterized by XRD.The results showed that during the degradation process,insoluble oligomers were produced first,and then soluble oligomers and D,L-lactide were produced,and the material lost mass rapidly,and finally PDLLA degraded completely.
- poly (D,L-lactic acid),
- D,L-lactide,
- normal saline,
- degradation
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