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Citation: ZHENG Jian-Bin, TAO Fu-Fang. Application of β-Cyclodextrin to Determination of Amoxicillin by Second Order Differential Simple Oscillographic Voltammetry[J]. Chinese Journal of Applied Chemistry, ;2005, 22(6): 595-599. shu

Application of β-Cyclodextrin to Determination of Amoxicillin by Second Order Differential Simple Oscillographic Voltammetry

ZHENG Jian-Bin ^, ,
TAO Fu-Fang

1.
Institute of Analytical Science, Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry, Northwest University, Xi'an 710069

Corresponding author: ZHENG Jian-Bin,
Received Date: 6 September 2004
Available Online: 4 December 2004
Fund Project: 国家自然科学基金(20275030) (20275030)陕西省自然科学基金资助项目(2004B20) (2004B20)

β-Cyclodextrin (β-CD) exhibits a pair of reversible peaks in the second order differential simple oscillgraphic voltammogram in a 0.2 mol/L NaOH solution,and the peak height decreases with the increase in the concentration of the inclusion complex of amoxicillin-β-CD.Based on the oscillographic characteristic of amoxicillin-β-CD,a second order differential simple oscillgraphic voltammetry method for determination of amoxicillin in capsule is presented.A linear response was observed in the range of 2.5×10^-6~3.0×10^-5 mol/L with a correlation coefficient of -0.997 9 and a detection limit of 1.0×10^-6 mol/L for amoxi-cillin.The relative standard deviation (RSD) for the determination of 1.5×10^-5 mol/L amoxicillin was 2.3% (n=5),and the average recovery rate was 100.1% (n=5).In addition,the inclusion ratio and inclusion constant (K) of amoxicillin-β-CD determined by the Job method were 1:1 and 6.0×10⁵,respectively.
- drug analysis,
- oscillographic analysis,
- oscillographic determination,
- β-cyclodextrin,
- amoxicillin
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