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Citation: WENG Wen, YAO Bi-Xia, LIU Feng, ZHU Jin, LI Sai-Qing. Influence of Mobile Phase Composition on Thermodynamic Parameters of Enantioseparation by Chiral Stationary Phase Derived from Tartaric Acid[J]. Chinese Journal of Applied Chemistry, ;2005, 22(7): 800-803. shu

Influence of Mobile Phase Composition on Thermodynamic Parameters of Enantioseparation by Chiral Stationary Phase Derived from Tartaric Acid

1.
Department of Chemistry, Zhangzhou Teachers College, Zhangzhou 363000

Corresponding author: WENG Wen,
Received Date: 28 September 2004
Available Online: 30 December 2004
Fund Project: 福建省高校重点科技项目基金(JA99210) (JA99210)福建省科技厅三项经费(K02092)资助 (K02092)

2-Benzoylamino-3-phenyl-propionic acid methyl ester was enantioseparated by HPLC with a chiral stationary phase (CSP) commercially named Kromasil CHI-DMB.This CSP contained a chiral immobilized network polymer derived from L-tartaric acid.The effects of the amount of polar modifier in the mobile phase on the chiral resolution and associated thermodynamic parameters were studied.The interactions,which involve hydrogen bonding principally,are believed to be important for the chiral recognition.The slow adsorption/desorption sites are released in low 2-propanol concentration.The separation factor was 1.661 for this amino acid derivative when n-hexane/2-propanol (volume ratio 99:1) was used as mobile phase at a flow rate of 1.0 mL/min and 25℃ with retention time being within 14 minutes.Benzoin was successfully enantio-separated when non-protonic modifier (THF) was used.The separation factor could reach to 1.168.
- chiral resolution,
- thermodynamic parameter,
- tartaric acid,
- amino acid derivative,
- benzoin
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