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Citation: YE Yan, LI Xiu-Juan, ZENG Zheng-Zhi. Synthesis, Anti-diabete and Antioxidative Action of Dimethylbiguamide Rare Earth Complexes[J]. Chinese Journal of Applied Chemistry, ;2005, 22(10): 1060-1064. shu

Synthesis, Anti-diabete and Antioxidative Action of Dimethylbiguamide Rare Earth Complexes

1.
College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000

Corresponding author: ZENG Zheng-Zhi,
Received Date: 27 December 2004
Available Online: 4 April 2005
Fund Project: 国家自然科学基金(20171019)资助项目 (20171019)

Four new complexes were synthesized via reaction of dimethylbiguamide(DMBG) with anhydrous Rare Earth chloride in anhydrous ethanol or Rare Earth acetate in ethanol,and characterized by elemental analysis,ICP,UV,IR,and fluorescence spectroscopy.The formulae of the complexes were established as Nd(DMBG)₂(EtO)Cl₂(EtO=ethoxy) and Re(DMBG)₂(CH₃COO)₃(Re=Nd(Ⅲ),Sm(Ⅲ)).Their anti-diabetes action on the diabetes mice was observed,and the elimination rates of supraoxide anion free radical on lipid were determinated by ESR.The result shows that Nd(DMBG)₂(CH₃COO)₃ complex exhibits a strong effect in both cases,which implies that its anti-diabetes action may be related to anti-oxidation action or protection effect to membrane damnication.
- dimethylbiguamide,
- rare earth complexes,
- anti-diabetes,
- antioxidative action
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