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Citation: QIAN Shao-Song, LIU Yi, CHEN Ran, LI Jia-You, WU Xiao-Yan, JIAO Qing-Cai. A Novel Preparation Method of C-Terminal Glutamine Dipeptides[J]. Chinese Journal of Applied Chemistry, ;2006, 23(1): 109-112. shu

A Novel Preparation Method of C-Terminal Glutamine Dipeptides

1.
College of Life Science, Nanjing University, Nanjing 210093

Received Date: 15 April 2005
Available Online: 28 July 2005

A novel synthesis method of dipeptides containing glutamine is reported.Protected L-amino acids were prepared by using inexpensive phthaloyl as the protecting group.Then the phthaloyl-L-amino acids were condensed with glutamine salts by the mixed anhydride method to afford phthaloyl dipeptides.Subsequently, the phthaloyl was removed from the dipeptides with hydrazine hydrate.As a result, optically pure glutamine-containing dipeptides were obtained in good yields.
- N-phthaloyl amino acids,
- L-alanyl-L-glutamine,
- Glycyl-L-glutamine,
- mixed anhydride
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