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Citation: WANG Ming-Hui, WU Jian-Ping, YANG Li-Rong, CHEN Xin-Zhi. Synthesis of 2-Chloro-3-Chloromethyl-thiophene and TiOconazole via Phase Transfer Catalysis[J]. Chinese Journal of Applied Chemistry, ;2006, 23(1): 106-108. shu

Synthesis of 2-Chloro-3-Chloromethyl-thiophene and TiOconazole via Phase Transfer Catalysis

1.
Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310027

Corresponding author: YANG Li-Rong,
Received Date: 27 February 2005
Available Online: 29 March 2005

The chloromethylation reaction of 2-chloro-thiophene via phase transfer catalysis was carried out to synthesize 2-chloro-3-chloromethyl-thiophene, where the catalyst was tetrabutylammonium bromide (TBAB).The chloromethylation reagents used were paraformaldehyde and 37% concentrated hydrochloric acid.The structure of 2-chloro-3-chloromethyl-thiophene was confirmed by means of GC-MAS, IR and ¹H NMR spectrometries.The yield was 77.6%.The O-alkylation reactions between 1-(2,4-dichloro-phenyl)-2-(1-imidazol)-ethanol and 2-chloro-3-chloromethyl-thiophene were performed in a two-phase system of organic solvent/solid NaOH under phase transfer catalytic condition.At the end, the tioconazole nitrate was formed by the addition of nitric acid.The structure of tioconazole was confirmed with IR and ¹H NMR spectra.The yield of tioconazole was 53.0%.
- phase transfer catalysis,
- chloro-chloromethyl-thiophene,
- chloromethylation,
- tioconazole
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