Citation:
ZOU Wei, SONG Jing-Yuan, XING Yong-Heng. Syntheses, Structures, Characterizations and Toxicities of Two Vanadium Complexes[J]. Chinese Journal of Applied Chemistry,
;2006, 23(1): 94-98.
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The new vanadium complexes VO(acac)(HB(pz)3)(1) and VO(acac) (HB(3,5-Me2pz)3)·CH3CN(2) with poly-pyrazolylborate as the ligand were synthesized.They were characterized by means of elemental analysis, IR, UV-Vis and 1H NMR techniques.In order to explore the possibility of using them as a medicine for diabetes, the toxicity of the vanadium complexes was tested by cell culture and MTT-reduction assay.Results show that the vanadium complexes can promote the growth of the cells when the concentration is lower than 10 μmol/L, but when the concentration is higher than 100 μmol/L, the survival rates decrease obviously.Toxicity is not seriously based on the active time; when it is lower than 10 μmol/L, the order of toxicity is (compound 1) >(compound 3) >(compound 2).It shows that vanadium complex (2) has a more feasibility to cure diabetes.
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Keywords:
- vanadium complex,
- tripyrazolylborate,
- cell toxicity test
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