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Citation: BAO Rui, LIU Cheng-Mei, QIU Jin-Jun, XU Yan. Synthesis and Drug Release Property of Unsaturated Polyphosphoester[J]. Chinese Journal of Applied Chemistry, ;2006, 23(1): 79-83. shu

Synthesis and Drug Release Property of Unsaturated Polyphosphoester

1.
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074

Corresponding author: LIU Cheng-Mei,
Received Date: 15 April 2005
Available Online: 8 October 2005
Fund Project: 国家自然科学基金(20374022) (20374022)

Unsaturated polyphosphoester(UPPE) containing fumarate segment in the repeat units was synthesized via condensation polymerization reaction with fumaric acid, 1,2-propylene glycol and phosphorous oxychloride as the raw materials.The structure of the polymer was characterized by FT-IR and NMR (¹H,¹³C, ³¹P).In vitro drug releases of the crosslinking systems of UPPE/NVP with different contents of ciprofloxacin and different mass ratios of UPPE to NVP were studied in phosphate buffer solution(pH=7.4) at 37℃.The results indicate that a system with a less content of ciprofloxacin releases drug more rapidly when the mass ratio of UPPE to NVP is kept constantly, and a system with a higher mass ratio of NVP to UPPE releases drug more rapidly when the content of ciprofloxacin is kept constantly.
- unsaturated polyphosphoester,
- bis (propyleneglycol) fumarate,
- biomaterial,
- drug release,
- ciprofloxacin
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