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Citation: HE Qiang-Fang, LI Guo-Ming, ZHU Jie-Min. Preparation and Drug Releasing Property of Magnetic Fluorouracil-loaded Chitosan Microspheres[J]. Chinese Journal of Applied Chemistry, ;2006, 23(2): 207-211. shu

Preparation and Drug Releasing Property of Magnetic Fluorouracil-loaded Chitosan Microspheres

1.
a Department of Chemistry, Guangdong Education institute, Guangzhou;
2.
b Department of Chemistry, South China Normal University, Guangzhou 510631

Corresponding author: LI Guo-Ming,
Received Date: 23 April 2005
Available Online: 27 July 2005

Magnetic fluorouracil-loaded chitosan microspheres were prepared by an emulsion chemical-crosslinking method.The Fe content was determined by titration with K₂Cr₂O₇.The magnetic susceptibility was measured by means of a magnetic balance,and the morphologies of the magnetic microspheres were observed under a scanning electron microscope.The results demonstrate that the magnetic fluorouracil-loaded chitosan microspheres exhibited strong paramagnetism with 4.55%~11.44%(mass fraction) of Fe₃O₄,1.86%~9.42%(mass fraction) of FU,39.48%~85.30% of which encapsulated,and the diameters were in the range of 1~10 μm.The drug releasing property was studied in the phosphate buffer(pH=7.4) solution,and the results show that FU could be released slowly from the microspheres with a longer release period;the content of Fe₃O₄ has an unconspicuous effect on drug release,and drug release was controlled by diffusion mechanism,and the drug releasing from the microspheres became faster with the increase of the drug content.The magnetic fluorouracil-loaded chitosan microspheres are a potential candidate as magnetic-targeting system for drug-controlled release.
- fluorouracil,
- chitosan,
- magnetic microsphere,
- sustained-release
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