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Citation: SUN Wei-Dong, GAO Fei-Fei, ZHANG Suo-Qin, LI Yao-Xian, ZHANG Guang-Liang. Synthesis and Characterization of Novel 2-Thiohydantoin Derivatives[J]. Chinese Journal of Applied Chemistry, ;2006, 23(5): 538-542. shu

Synthesis and Characterization of Novel 2-Thiohydantoin Derivatives

1.
a College of Chemistry, Jilin University, Changchun 130021;
2.
b Department of Chemistry, Chifeng College, Chifeng

Corresponding author: ZHANG Suo-Qin,
Received Date: 27 June 2005
Available Online: 28 October 2005

Novel 2-thiohydantoin derivatives were synthesized,and the structures of the title compounds were confirmed by ¹H NMR,¹³C NMR,and IR.The preliminary biological tests of the title compounds were carried out.The structure-activity relationship was analyzed from structure characteristic and substituent effect.The results show that 5-methyl-2-thiohydantoin derivatives exhibit higher biological activity than those without 5-methyl.The maximum inhibiting rate is 56.5%(sprout) and 53.8%(root).2-Thiohydantoin derivatives can be made into novel pesticide precursor compounds.
- acetohydroxyacid synthase,
- sulfonylurea,
- thiohydantoin,
- synthesis
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