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Citation: ZHAO Jin, BU Zhan-Wei, Liu Yang, WANG Chao-Jie. Synthesis and Biological Activity of New Solanesyl Nitrogen Mustards[J]. Chinese Journal of Applied Chemistry, ;2006, 23(5): 514-518. shu

Synthesis and Biological Activity of New Solanesyl Nitrogen Mustards

1.
College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475001

Corresponding author: WANG Chao-Jie,
Received Date: 3 July 2005
Available Online: 15 November 2005
Fund Project: 河南省科技厅(0323024000,0424410030) (0323024000,0424410030)

Four solanesyl nitrogen mustards were designed and synthesized with solanesol or solanesyl amine as the carrier,maleic acid and phthalic acid as the linkers,and nitrogen mustard as the pharmacophore.Four similar nitrogen mustard derivatives were also prepared with the linear aliphatic alcohols instead of solanesyl derivatives as the carrier to compare their difference.The structures of the compounds were confirmed by IR,¹H NMR,MS and elemental analysis.The in vitro anti-tumor activities of these compounds were tested preliminarily on KB,Bel-7402,HCT-8,A549 and MDA cells.The data show that the nitrogen mustard with solanesol as the carrier and maleic acid as the linker inhibits all the five tested cells.
- nitrogen mustard,
- solanesol,
- synthesis,
- biological activity
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