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Citation: SONG Qing-Ping, YUE Wen-Jin, DING Chun-Mei. Preparation of Carboxymethyl Chitosan by Low-Alkali Method and Its Characterization[J]. Chinese Journal of Applied Chemistry, ;2006, 23(8): 913-917. shu

Preparation of Carboxymethyl Chitosan by Low-Alkali Method and Its Characterization

1.
Department of Biochemical Engineering, Anhui University of Technology and Science, Wuhu 241000

Corresponding author: DING Chun-Mei,
Received Date: 9 October 2005
Available Online: 2 December 2005
Fund Project: 安徽省教育厅自然科学基金重点项目(2003kj008zd) (2003kj008zd)

With chitosan and sodium chloroacetate as the reactants and water as the reaction solvent, carboxymethyl chitosan(CMC) was synthesized by a new kind of method,i.e.,low-alkali method.The dependence of the degree of substitution of the CMC on the ratio of reactants,reaction temperature,reaction time and amount of catalyst was investigated.The result shows that the best reaction conditions for synthesizing CMC with a high degree of substitution(1.68) are that the ratio of chitosan to sodium chloroacetate is 1:5, reaction temperature is 90℃,reaction time is 5 h,and the amount of catalyst is 3%.The method is much better than using an alcohol-water mixed solvent.Physicochemical properties,such as solubility,isoelectric point,moisture absorption,intrinsic viscosity,were also studied.Finally,the CMC was characterized by IR,TGA and XRD.
- chitosan,
- carboxymethyl chitosan,
- degree of substitution,
- intrinsic viscosity,
- low-alkalimethod
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