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Citation: LU Hong-Fei, LU Ming, ZHANG Li-Juan. Syntheses of 2-Halogenopurine Derivatives[J]. Chinese Journal of Applied Chemistry, ;2006, 23(10): 1156-1160. shu

Syntheses of 2-Halogenopurine Derivatives

1.
College of Chemistry Engineering, Nanjing University of Science and Technology, Nanjing 210094

Corresponding author: LU Ming,
Received Date: 16 November 2005
Available Online: 12 January 2006

A series of 2-halogenopurine derivatives was synthesized from guanine through diazotization.All the products were characterized by ¹H NMR,MS and elemental analysis.Fungicidal activities of all the compounds were tested.Good fungicidal activity was observed for 5a,5c,5g and 5h against Bacillus subtillis,5b and 5c against Aspergillus niger,and 5f against Cardida tropicals.Density functions of all the compounds were calculated using Gaussian 98,and the effect of different groups on the net charges of C(2) were discussed.
- purine,
- diazotization,
- synthesis,
- fungicidal activity
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