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Citation: RAO Yan-Ping, PAN Chun-Yue, LAI Jin-Hong. Swelling and Drug Releasing Properties of P(NIPAAm-co-AAm) Hydrogels and PAAc/P(NIPAAm-co-AAm) IPN Hydrogels[J]. Chinese Journal of Applied Chemistry, ;2006, 23(10): 1129-1134. shu

Swelling and Drug Releasing Properties of P(NIPAAm-co-AAm) Hydrogels and PAAc/P(NIPAAm-co-AAm) IPN Hydrogels

1.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083

Corresponding author: PAN Chun-Yue,
Received Date: 30 November 2005
Available Online: 9 March 2006

P(NIPAAm-co-AAm) and interpenetrating polymer network(IPN) hydrogels,PAAc/P(NIPAAm-co-AAm) with different compositions were prepared from acrylic acid(AAc),N-isopropylacrylamide(NIPAAm),and acrylamide(AAm) through free radical polymerization,in which N,N'-methylenebisacry-lamide(BIS) was used as a crosslinking agent.The swelling and drug releasing properties of these hydrogels with different thermosensitive properties were studied.The influence of the amount of AAm on the properties of these hydrogels was investigated.Experimental results revealed that these copolymer gels showed negative temperature sensitivity.When the molar ratio of AAm to NIPAm increased to 3:1 from 1:3,the effective crosslinking density of the copolymer gels increased to 3.071×10^-6 mol/cm³ from 2.518×10^-6 mol/cm³,and the equilibrium swelling ratio decreased to 15.36 from 18.65;thermosensitivity became weaker,and sodium salicylate releasing ratio of the copolymer gels reduced from 95.30% to 75.55%,and salicylic acid releasing ratio increased from 29.87% to 66.12%.However,IPN gels showed positive temperature sensitivity.With increasing the molar ratio of AAm to NIPAm from 1:3 to 3:1,the effective crosslinking density of IPN gels decreased from 31.06×10^-6 mol/cm³ to 26.92×10^-6 mol/cm³,and the equilibrium swelling ratio increased to 8.792 from 1.816;thermosensitivity of the IPN gels increased,and sodium salicylate releasing ratio increased from 41.56% to 59.65%,and salicylic acid releasing ratio also increased from 43.77% to 66.55%.
- N-isopropylacrylamide,
- acrylamide,
- acrylic acid,
- copolymerization,
- interpenetrating polymer network(IPN),
- hydrogel,
- swelling,
- drug release
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