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Citation: ZHANG Juan, FAN Xiao-Dong, LIU Yi-Feng, HUANG Jing. Synthesis and Characterization of 5-(Aryloxymethyl)-2-Oxazolidinones[J]. Chinese Journal of Applied Chemistry, ;2006, 23(12): 1401-1403. shu

Synthesis and Characterization of 5-(Aryloxymethyl)-2-Oxazolidinones

1.
a Department of Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072;
2.
b Applied Chemical Institute, Northwest University, Xi'an

Corresponding author: ZHANG Juan,
Received Date: 13 November 2005
Available Online: 1 March 2006
Fund Project: 国家自然科学基金资助项目(20374040) (20374040)

5-chloromethyl-2-oxazolidinone was prepared in a yield of 75.2% by the reaction of epichlorohydrin,sodium cyanate and magnesium sulfate(molar ratio,1:2:2) in water(10 mL/g epichlorohydrin) at 90~95℃ for 1.5 h.The phenols were first converted to sodium phenolate by the reaction of phenol and sodium hydroxide in methanol,then 5-(aryloxymethyl)-2-oxazolidinones were synthesized in 65%~80% yields by the reaction of sodium phenolate and 5-chloromethyl-2-oxazolidinone(molar ratio,1:1) in DMSO at 150℃ for 3 h.Title compounds were characterized by means of ¹H NMR,IR and elemental analysis.
- epichlorohydrin,
- chloromethyl-oxazolidinone,
- synthesis,
- (aryloxymethyl)oxazolidinones
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