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Citation: FENG Juan, Luo Xiao, Mu Yun, LIU Shou-Xin. The Electrophilic Reaction of NBS with Substituted Benzene and its Application[J]. Chinese Journal of Applied Chemistry, ;2007, 24(1): 111-113. shu

The Electrophilic Reaction of NBS with Substituted Benzene and its Application

FENG Juan ^a ,
Luo Xiao ^a,b ,
Mu Yun ^a ,
LIU Shou-Xin ^a,,

1.
a College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018;
2.
b College of Chemistry and Environment Science, Hebei University, Baoding

Corresponding author: LIU Shou-Xin,
Received Date: 5 January 2006
Available Online: 26 April 2006

Toluene with different substituted group was selected to react with NBS under diffent conditions.The factors that effect reaction including the polarity of solvent, the electron effect of substituteed group and reaction temperature were discussed.The results indicated that the regioselectivity of substitutent reaction depend greatly on reaction solvent and the electronic effect of substitutent group.It is shown that the electro-phic substitution of benzene ring is favored in more polar solvents and for compounds with strong electron-donating groups.Otherwise, the free radical reaction in the α-site was favorable.On the base of the results, a new synthetic route of brominated Q0 was reported.The method was more favorable for the preparation of Q0, and the yield was above 86%.
- NBS,
- substituted benzene,
- electrophilic substitution,
- brominated Q
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