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Citation: YI Bing, XIE Zhi-Ming, DANG Li-Min. Improvement on Synthesis of (3S,4S)-N-Benzyl-3,4-dihydroxy Pyrrolidine[J]. Chinese Journal of Applied Chemistry, ;2007, 24(2): 223-225. shu

Improvement on Synthesis of (3S,4S)-N-Benzyl-3,4-dihydroxy Pyrrolidine

1.
Department of Chemistry and Chemical Engineering, Hunan Institute of Engineering, Xiangtan 411104

Corresponding author: YI Bing,
Received Date: 26 March 2006
Available Online: 6 August 2006
Fund Project: 湖南省教育厅优秀青年项目(068021) (068021)湖南工程学院科研启动基金资助(120637) (120637)

(3S,4S)-N-benzyl-3,4-dihydroxy pyrrolidine was synthesized using NaBH₄/I₂ as the reducing agent in THF.The effect of the molar ratio of the starting materials,the reaction time,and the type of reducting agents were explored.Under the optimum condition,i.e.,the molar ratio of substrate to NaBH₄ and I₂ was 1:5:1.67,and the refluxing reaction time was 6 h,the yield was up to 70%.The product was charac-terized by ¹H and ¹³C NMR spectroscopy,and all the results were consistent with the compounds synthesized. Compared with the conventional synthetic method,the method has such advantages as inexpensive reagents, simple operation,and easy scaling up.
- (3S,4S)-N-benzyldihydroxy pyrrolidine,
- NaBH₄/I₂,
- synthesis
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