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Citation: YANG Chun-Yan, XIONG Yan, HE Chao, ZHANG Zhu-Jun. Molecularly Imprinted On-line Solid-phase Extraction Combined with Flow Injection Chemiluminescence for Determination of Chlortetracycline[J]. Chinese Journal of Applied Chemistry, ;2007, 24(3): 273-277. shu

Molecularly Imprinted On-line Solid-phase Extraction Combined with Flow Injection Chemiluminescence for Determination of Chlortetracycline

1.
School of Chemistry and Chemistry Engineening, Southwest Normal University, Chongqing 400715

Corresponding author: ZHANG Zhu-Jun,
Received Date: 23 March 2006
Available Online: 13 June 2006
Fund Project: 国家自然科学基金资助项目(30470886) (30470886)

Chlortetracycline hydrochloride can enhane the chemiluminescence of Ce(Ⅳ) and Rh6G in acidic medium. So novel molecularly imprinted polymer solid-phase extraction(MISPE) method combined with flow-injection chemiluminescence for determining chlortetracycline hydrochloride was developed. The MIP was synthesized by using tetracycline as the imprinting molecule which has a structure similar to that of chlortetracycline. A polytetrafluoroe-thylene(PTFE) tube packed with the particles of MIP was employed as an MISPE micro-column and was connected to the sampling loop of the eight-way injection valve for the preconcentration and extraction of chlortetracycline hydrochloride. The eluent was used as the carrier for extracting the adsorbed chlortetracycline hydrochloride to react with a mixture of cerium(Ⅳ) and rhodamine6G in the flow cell to produce strong CL. Intensity of CL is linearly changed with the concentration of chlortetracycline hydrochloride from 2×10^-8 g/mL to 1×10^-6 g/mL and the limit detection is 4×10^-9 g/mL(3σ). This method has been successfully applied to the determination of chlortetracycline hydrochloride in liver of chicken sample.
- molecularly imprinted polymer,
- solid phase extraction,
- chemiluminescence,
- flow-injection,
- chlorte-tracycline
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