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Citation: XUE Ping, YAN Xiang-Hui. One-pot Reduction and Transesterification Resolution of Acetophenone Catalyzed by Lipase Immobilized on MCM-48 Coated Chitosan[J]. Chinese Journal of Applied Chemistry, ;2007, 24(3): 245-250. shu

One-pot Reduction and Transesterification Resolution of Acetophenone Catalyzed by Lipase Immobilized on MCM-48 Coated Chitosan

XUE Ping ^, ,
YAN Xiang-Hui

1.
Key Laboratory of Energy Resources and Chemical Engineering, Ningxia University, Yinchuan 750021

Corresponding author: XUE Ping,
Received Date: 27 April 2006
Available Online: 31 August 2006
Fund Project: 国家重大基础研究前期研究专项项目(2004CCA05900) (2004CCA05900)

A new compound material CS-MCM-48 was prepared by coating chitosan(CS) on mesoporous molecular sieve MCM-48. When the mass ratio of CS to MCM-48 was adjusted to 1:10, the specific surface area, average pore diameter and pore volume of CS-MCM-48(1:10) reached 408 m²/g, 2.14 nm and 0.38 cm³/g, respectively. The lipase(Pseudomonas Cepacia Lipase, PSL) was immobilized on the CS-MCM-48 in a mixed solvent of phosphate buffer solution and isooctane and used for one-pot reduction and transesterification synthesis of pure enantiomers from prochiral acetophenone. The results indicate that PSL immobilized on CS-MCM-48 possessed much higher catalytic transesterification activity and enantioselectivity than on single MCM-48 or CS. The enantiomeric excess of products (S)-1-phenylethanol and (R)-1-phenylethyl acetate reached respectively 18.0% and 99% with a 1-phenylethanol conversion of 15.3% and an enantioselectivity E value of 237 in toluene at 40℃, which showed the immobilized lipase PSL/CS-MCM-48 exhibited conside-rable chiral resolution properties.
- CS-MCM-48 compound support,
- immobilized lipase,
- one-pot,
- acetophenone resolution,
- enantioselectivity,
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