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Citation: WANG Li-Zeng, JIANG Lin, WANG Li-Yin, ZHANG Deng-Ke. Synthesis and Biological Activity of N-(4,6-Disubstituted pyrimidin-2-yl)-N'-(1-methyl-3-ethyl-4-chloropyrazol-5-yl)formyl(thio)urea[J]. Chinese Journal of Applied Chemistry, ;2007, 24(11): 1284-1288. shu

Synthesis and Biological Activity of N-(4,6-Disubstituted pyrimidin-2-yl)-N'-(1-methyl-3-ethyl-4-chloropyrazol-5-yl)formyl(thio)urea

1.
College of Chemistry and Material Science, Shandong Agricultural University, Tai'an 271018

Corresponding author: JIANG Lin,
Received Date: 18 December 2006
Available Online: 15 February 2007
Fund Project: 山东省教育厅科研基金(J01C10)资助项目 (J01C10)

Five new N-(4,6-disubstituted pyrimidin-2-yl)-N'-(1-methyl-3-ethyl-4-chloropyrazol-5-yl)formylurea compounds and five new N-(4,6-disubstituted pyrimidin-2-yl)-N'-(1-methyl-3-ethyl-4-chloropyrazol-5-yl)formylthiourea compounds were synthesized with 1-methyl-3-ethyl-4-chloropyrazol-5-yl formic acid and 2-amino-4,6-disubstituted pyrimidine as raw materials. The structures of the title compounds were characterized by IR, ¹H NMR and elemental analysis. The preliminary bioassay tests show that they have not satisfying acaricidal activity, but some of them have herbicidal activity to some extent. For example, the inhibition rate of compounds Ⅰ_b, Ⅰ_c and Ⅰ_e against Barnyard grass at a dosage of 50 mg/L are 61%, 61% and 67%, respectively.
- pyrazole formylurea,
- pyrazole formylthiourea,
- synthesis,
- acaricidal activity,
- herbicidal activity
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