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Citation: CHEN Hai-Ying, LU Ming. Preparation of Aryltrifluoroethyl Ether Derivatives[J]. Chinese Journal of Applied Chemistry, ;2008, 25(1): 111-115. shu

Preparation of Aryltrifluoroethyl Ether Derivatives

CHEN Hai-Ying ,
LU Ming ^,

1.
Chemical Engineering School, Nanjing University of Science and Technology, Nanjing 210094

Corresponding author: LU Ming,
Received Date: 21 January 2007
Available Online: 2 April 2007

A simple and effective method to prepare 2,2,2-trifluoroethyl ethers via direct nucleophilic substitution was introduced.Some trifluoroethyl aryl derivatives were obtained from the aryl derivatives with sodium 2,2,2-trifluoroethylate in the presence of CuI.Some trifluoethoxylpyridine ether derivatives were successfully synthesized by reacting 4-nitro-pyridine-N-oxide derivatives with trifluoroethanol in the presence of alkali.Especially the yield of 4-(2,2,2-trifluoroethoxy) phenol,which has not been reported in literature up to now,can reach 83.6%.The products were determined by ¹H NMR,IR,MS and elemental analysis.The effects of catalyst amount,solvent and temperature on the trifluoroethylation reaction of 4-bromophenol were discussed,the yield was 85.93% when the molar ratio of 4-bromophenol and CuI was 1:4,in DMAC at 130℃;the effects of alkali amount and temperature on the trifluoroethylation reaction of 2,3-dimethyl-4-nitropyridine-N-oxide were also discussed.The yield was 89.5% when mass ratio of trifluoroethanol and potassium hydroxide was 10:1,and the temperature was 90℃.
- aryltrifluoroethyl ethers,
- preparation,
- nucleophilic substitution,
- trifluoroethanol
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