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Citation: LI Lai-Sheng, XU Li-Li, YANG Han-Rong, LIU Miao-Fen. Separation of Basic Compounds on Curcumin-bonded Silica Stationary Phase by HPLC[J]. Chinese Journal of Applied Chemistry, ;2008, 25(1): 95-100. shu

Separation of Basic Compounds on Curcumin-bonded Silica Stationary Phase by HPLC

1.
Analytical and Testing Center, Nanchang University, Nanchang 330047

Corresponding author: LI Lai-Sheng,
Received Date: 2 February 2007
Available Online: 8 May 2007
Fund Project: 江西省教育厅科技项目基金资助项目(JJ2007-18) (JJ2007-18)

High-performance liquid chromatographic behavior of eleven basic compounds on a new curcumin bonded silica gel stationary phase(CCSP) was studied.The effects of mobile phase variables,such as methanol content and pH,on their chromatographic behavior,as well as the silanophilic activity of the CCSP were investigated.The retention behavior of the basic compounds was compared with that on ODS.The retention mechanisms of these solutes on the CCSP were also discussed.The results indicate that baseline separation of three series of basic compounds on the CCSP(no end-capped) can be achieved with methanol(55%,40%,30%,respectively)-water as a binary mobile phase without addition of a buffer solution.Compared with ODS,the CCSP exhibited better separation selectivity.Moreover,the elution orders of N,N-dimethylaniline and β-naphthylamine,N-methylaniline and m-nitrobenzaldehyde were very different under the same chromatographic conditions,which indicated that the two stationary phases under went different retention mechanisms in the chromatographic processes.According to the chromatographic data,the separation of the above compounds on the CCSP was based on hydrophobic interaction,n-π and π-π interactions,dipole-dipole interaction,hydrogen-bonding interaction,and charge transfer interaction.The CCSP has the advantages of fast and effective separation for basic compounds with more symmetrical peak shape using simple methanol-water mobile phase,and the capacity factor(k') of these solutes decreases with the increase of methanol content on CCSP without occurrence of the "U" shape.
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