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Citation: LI Gui-Yin, HUANG Ke-Long, JIANG Yu-Ren, DING Ping. Thermodynamic Studies on Enantiomer Separation of Mandelic Acid by Chiral Ligand-exchange HPLC[J]. Chinese Journal of Applied Chemistry, ;2008, 25(1): 9-12. shu

Thermodynamic Studies on Enantiomer Separation of Mandelic Acid by Chiral Ligand-exchange HPLC

1.
a College of Chemistry and Chemical Engineering, Central South University, Changsha 410083;
2.
b Hunan Vocational College of Science and Technology, Changsha

Corresponding author: HUANG Ke-Long,
Received Date: 18 January 2007
Available Online: 16 April 2007
Fund Project: 国家自然科学基金资助项目(20376085) (20376085)

The effect of temperature(293~313 K) on chromatographic separation of mandelic acid over a C₁₈ column was investigated with L-phenylalanine-CuSO₄ aqueous solution and methanol as the chiral ligand mobile phase.Higher column temperature was found to be disadvantageous to the enantiomer separation.The retention time,resolution and selectivity of the chiral separation were decreased with temperature increase.The Van't Hoff plots of the ln k' versus 1/T of the enantiomers have a good linearity with a correlation coefficient of 0.99.The thermodynamic functions(ΔH⁰,Δ_S,RΔH⁰,Δ_S,RΔS⁰) were calculated,and in the examined temperature range,the enthalpy contribution to the enantiomer transfer energy was found to be more significant than the entropy one.Therefore,the enantiomeric separation is a enthalpy controlling process.
- chiral ligand,
- mandelic acid,
- enantiomer separation,
- thermodynamic property
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