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Citation: XIA Lin, HU Ai-Xi, TAN Ying, CHEN Hui. Release of Naproxen from Intelligent Drug Delivery System[J]. Chinese Journal of Applied Chemistry, ;2008, 25(2): 237-240. shu

Release of Naproxen from Intelligent Drug Delivery System

1.
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082

Corresponding author: HU Ai-Xi,
Received Date: 20 February 2007
Available Online: 20 July 2007

Aqueous gels(NIPA-co-MAA) containing naproxen were encapsulated with cellulose acetate membrane,and then drug release was performed under a simulated body environment.A newly intelligent drug delivery system was established to research the releasing of naproxen in the systems.It was identified that the drug in the hydrogel material could be delivered at fairly high release ratio at 37℃.Furthermore,the drug was released at a slower ratio(2%~5%) in the simulated gastric juice,but at a higher releasing ratio in intestines juice.The more PEG,the higher the releasing ratio.When the membrane contained 50% PEG,the releasing ratio was 40%.It is a good way to avoid the side effect caused by the drug absorption in stomach.
- aqueous gel,
- naproxen,
- ellulose acetate,
- drug delivery system,
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