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Citation: GAN Ning, LI Tian-Hua, WANG Lu-Yana. Electrochemical Biosensor for Homocysteine in Serum by Ru(Ⅱ) Phthlocyanine Self-assembly Electrode[J]. Chinese Journal of Applied Chemistry, ;2008, 25(2): 189-193. shu

Electrochemical Biosensor for Homocysteine in Serum by Ru(Ⅱ) Phthlocyanine Self-assembly Electrode

1.
a State Key Laboratory of Novel Functional Materials and Preparation Science, Ninbo University, Ningbo;
2.
b Faculty of Life Science, Nanjing Univerisity, Nanjing

Corresponding author: GAN Ning,
Received Date: 10 February 2007
Available Online: 26 April 2007
Fund Project: 浙江省科技攻关项目(2006C31040) (2006C31040)宁波市自然科学基金(2006A610048)资助项目 (2006A610048)

One monolayer containing thiol-tailed groups was formed via the covalent binding of Ru(Ⅱ) phthlocyanine(RuPc) on a dimercaptosuccinic amine-modified gold electrode by self-assembly,which was characterized by IR and XPS.The modified gold electrode showed an excellent electrocatalytic activity for the oxidation of homocysteine(Hcy) in a phosphate buffer solution(pH=5.5).The electrocatalytic mechanism and effect of pH of the buffer solution were also investigated.The steady-state current of chronoamperometry increased linearly with Hcy concentration in the range of 5.0×10^-7~5.4×10^-5 mol/L with a detection limit of 0.18 μmol/L(S/N=3).The sensor also showed excellent reproducibility that makes it an ideal amperometric detector for Hcy in human serum.
- Au electrode,
- self-assembled monolayer,
- electrochemical catalysis,
- Ru(Ⅱ)phthlocyanine,
- homocysteine
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