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Citation: LIU Gang, CHEN De-Jun, WANG Ji-De, SUN Wan-Fu. Isomerization Mechanism of L-Ephedrine Hydrochloride to D-Pseudoephedrine Hydrochloride[J]. Chinese Journal of Applied Chemistry, ;2008, 25(2): 173-176. shu

Isomerization Mechanism of L-Ephedrine Hydrochloride to D-Pseudoephedrine Hydrochloride

LIU Gang ^a ,
CHEN De-Jun ^a ,
WANG Ji-De ^a,, ,
SUN Wan-Fu ^b

1.
a Department of Chemistry and Chemical Engineering, MOE Key Laboratory of Oil & Gas Fine Chemicals, Xinjiang University, Urumqi 830046;
2.
b Physical and Chemical Analysis Center, Xinxiang University, Urmuqi

Corresponding author: WANG Ji-De,
Received Date: 9 February 2007
Available Online: 30 June 2007
Fund Project: 国家自然科学基金(20461003)资助项目 (20461003)教育部新世纪优秀人才支持计划(NCET-04-0987) (NCET-04-0987)高等学校博士学科点专项科研基金(20050755003)资助项目 (20050755003)

To understand the isomerization mechanism from L-ephedrine hydrochloride to Dipseudoephedrine hydrochlroride,the intermediate products were obtained by controlling reaction condition of the isomerization and characterized by ¹H NMR,¹³C NMR,2D-NMR and single crystal X-ray diffraction.The absolute construction was determined from above results,and the mechanism was determined.
- ephedrine,
- aceted intermediate,
- mechanism,
- absolute construction,
- 2D-NMR
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