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Citation: LIU Jian-Chao, CHEN Qi-Yuan. Advances in Synthesis and Applications of Thieno[2,3-b] pyridine Derivatives[J]. Chinese Journal of Applied Chemistry, ;2008, 25(2): 125-131. shu

Advances in Synthesis and Applications of Thieno[2,3-b] pyridine Derivatives

LIU Jian-Chao ^a,, ,
CHEN Qi-Yuan ^b

1.
a College of Chemistry, Central China Normal University, Wuhan 430079;
2.
b College of Chemistry and Chemical Enginnering, Central South University, Changsha 410083

Corresponding author: LIU Jian-Chao,
Received Date: 26 April 2007
Available Online: 23 July 2007
Fund Project: 国家自然科学基金资助项目(20203009) (20203009)

Thieno[2,3-b]pyridine derivatives are of great importance because of their remarkable biological properties.They are of chemical and pharmacological interests due to their isosterism with quinolines and isoquinolines,two important heterocycles involved in many alkaloids.Some of them have been used as herbicides,fungicides,pesticides,medicines and dyes.Three general routes have been described so far for the preparation of thieno[2,3-b]pyridine derivatives of this ring system:a)formation of the thiophene ring by cyclization of suitable substitutents of a pyridine;b)formation of the pyridine ring by cyclization of a suitable thiophene;c)condensation of unsaturated thionone derivatives.This paper reviews the advances in synthesis and applications of thieno[2,3-b]pyridine derivatives.
- thieno[2,
- 3-b]pyridine derivative,
- biological activity,
- medicine,
- agricultural chemical,
- synthesis
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