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Citation: ZHENG Li-Ling, XU Guang-Lin, AO Gui-Zhen, WU Zhou. Synthesis and Anti-inflammatory Activity of α-Substituted 3,5-Dimethoxyphenylpropenoic Acid Derivatives[J]. Chinese Journal of Applied Chemistry, ;2008, 25(4): 481-484. shu

Synthesis and Anti-inflammatory Activity of α-Substituted 3,5-Dimethoxyphenylpropenoic Acid Derivatives

1.
a College of Pharmacentical Science, Suzhou University, Suzhou 215123;
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b Center for Drug Research and Development, College of Life Science, Nanjing Normal University, Naijing

Corresponding author: AO Gui-Zhen,
Received Date: 15 April 2007
Available Online: 4 July 2007

Nine α-substituted 3,5-methoxyphenylpropenoic acids (Ⅰ_1~9) were synthesized from 3,5-dimethoxy-benzaldehyde and aryl acetic acids by Perkin reaction respectively.Ⅰ₁₀ was obtained through the reduction of Ⅰ₇ with iron power,and Ⅰ₁₁ was obtained through acetylation of Ⅰ₁₀.The structures of these novel compounds whose structures were identified by ¹H NMR,IR and HR-MS.Preliminary pharmacological tests on xylene-induced mice ear swelling model demonstrated that most of the target compounds had anti-inflammatory activity,especially compounds Ⅰ₆,Ⅰ₉ and Ⅰ₁₁,compared with positive control aspirin (P<0.05,P<0.01).
- α-substituted methoxyphenylpropenoic acids,
- Pekin reaction,
- anti-inflammatory activity
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