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Citation: ZHANG Xiu-Li, LÜ Xian-Hai, JIANG Wan-Quan. Synthesis and Fungicidal Activity of New Pyrazole-Acyl Fluoro-Substituted Aromatic Thiourea Derivatives[J]. Chinese Journal of Applied Chemistry, ;2008, 25(4): 459-463. shu

Synthesis and Fungicidal Activity of New Pyrazole-Acyl Fluoro-Substituted Aromatic Thiourea Derivatives

1.
a College of Science, Anhui Agricultural University, Hefei 230036;
2.
b Department of Chemistry, University of Science and Technology of China, Hefei

Corresponding author: ZHANG Xiu-Li,
Received Date: 24 December 2007
Available Online: 8 March 2008
Fund Project: 合肥市重点科技项目(合科2006[032]) (合科2006[032])安徽省科技厅重点科研项目(06023092C) (06023092C)安徽省教育厅青年教师基金(2007jq1054)资助项目 (2007jq1054)

Nine novel pyrazole-acyl fluoro-substituted aromatic thiourea derivatives were synthesized from phenylhydrazine and ethyl acetoacetate.The intermediate 4 was prepared via a series of reactions involving cyclization,formylation,oxidation and acylation,and was subsequently reacted with amonium thiocyanate to generate the corresponding intermediate 5 with good yield in the presence of phase transfer catalyst PEG-600.The obtained intermidiate 5 was then reacted with fluoro-substituted anilines to form the desired pyrazole-acyl fluoro-substituted aromatic thiourea derivatives,and their structures were identified by IR,¹H NMR and elemental analysis.Preliminary bioassays indicated that compounds 6a,6b,6d,6e,6f,6g,6h and 6i showed inhibitory activities (100%) against Rhizoctonia sasakii,and compound 6e showed inhibitory activities (98.2%) against Gibberella zeae at a concentration of 50 mg/L.
- pyrazol,
- acyl thiourea,
- fluoro-substituted aniline,
- synthesis,
- fungicidal activity
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