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Citation: LUO Yi-Ming, XIAO Lin-Xiang, TANG Rui-Ren, CHEN Zhe. Synthesis of 2,6-Bis(p-Methoxybenzoylactyl) Pyridine[J]. Chinese Journal of Applied Chemistry, ;2008, 25(4): 433-436. shu

Synthesis of 2,6-Bis(p-Methoxybenzoylactyl) Pyridine

1.
School of Chemistry and Chemical Engineering, Central South University, Changsha 410083

Corresponding author: LUO Yi-Ming,
Received Date: 5 April 2007
Available Online: 1 August 2007
Fund Project: 湖南省科技厅计划资助项目(05JT1022) (05JT1022)

2,6-Bis(p-methoxybenzoylactyl) pyridine was synthesized via esterification and Claisen condensation reaction with pyridine-2,6-dicarboxylic acid as starting material.The reaction conditions were investigated in detail.The product was determined by IR,¹H NMR and elemental analysis.The experimental results show that the product was 2,6-bis(p-methoxybenzoylactyl) pyridine and its yield was more than 85.5% under the reaction conditions of molar ratio of dimethyl pyridine-2,6-dicarboxylate to p-methoxy acetophenone and sodium 1:2.4:2.4,prophase reaction temperature 110℃,anaphase reaction temperature 100℃ with p-methoxy acetophenone toluene solution being put drop by drop into dimethyl pyridine-2,6-dicarboxylate toluene solution.
- bis(p-methoxybenzoylactyl) pyridine,
- claisen condensation,
- synthesis
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