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Citation: SUN Le, FAN Xiao-Dong, LIU Yu-Yang, WANG Liang. Synthesis and Characterization of Cyclodextrin Modified by Amino Acids[J]. Chinese Journal of Applied Chemistry, ;2008, 25(4): 405-408. shu

Synthesis and Characterization of Cyclodextrin Modified by Amino Acids

1.
Department of Chemistry, School of Science, Northwestern Polytechnical University, Xi'an 710072

Received Date: 10 May 2007
Available Online: 26 August 2007
Fund Project: 国家自然科学基金资助项目(20674060) (20674060)西北工业大学青年教师创新基金资助项目(w016218) (w016218)

We used glycin,L-tryptophan,L-glutamic acid and L-aspartic acid as substrates to react with 6-OTs-β-CD to yield amino acid modified β-cyclodextrinunder.The yields of the targeted compounds 2a~2d were 65.3%,27.9%,44.6% and 40.0%,respectively.It was determined that the optimum mass ratio between triethanolamine and water was 2:3.When the mole ratio between amino acid and cyclodextrin was 3:1,the yield was the best.The products were purified by chromatography on a Sephadex G-25 column with deionizated water as eluent,followed by recrystallization from water and ethanol.The molecular structures of the products were studied using FTIR,MS,¹H NMR,¹³C NMR and element analysis.
- cyclodextrin derivative,
- amino acid,
- synthesis,
- sephadex,
- recrystallization
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