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Citation: CHEN Yan, SHEN He-Bai, XU Rui-Yun, ZHU Long-Zhang. Preparation and Characterization of Chitosan/5-Fluorouracil Nanoparticles[J]. Chinese Journal of Applied Chemistry, ;2008, 25(5): 564-568. shu

Preparation and Characterization of Chitosan/5-Fluorouracil Nanoparticles

1.
a College of Life and Environment Science, Shanghai Normal University, Shanghai 200234;
2.
b College of Chemical Engineering, Shanghai Institute of Technology, Shanghai

Corresponding author: SHEN He-Bai,
Received Date: 6 June 2007
Available Online: 28 August 2007
Fund Project: 上海市科委(05DE193272)资助项目 (05DE193272)

Chitosan/5-fluorouracil nanoparticles (CS/5-Fu NPs) were prepared by microemulsion-ionic crosslinking method with Na₂SO₄ and Na₅P₃O₁₀ used as crosslinkers.These NPs were monodispersed and uniformly spherical.NPs prepared by Na₂SO₄ were about 100 nm in size,with the drug loading efficiency (LE) and ecapsulation efficiency (EE) amounting to 30% and 80%,respectively.NPs prepared by Na₅P₃O₁₀ were 40~80 nm in size,with LE and EE amounting to 21% and 55%,respectively.Sustained-release experiment was carried out in HCl solution (pH=1) and phosphate buffered solution (pH=7.4),which showed that the drug releasing amount increased with the releasing time extended,and the drug releasing performance was better in phosphate buffered solution.When cultured with the NPs,the apoptosis of K562 tumor cells was increased with the releasing time extended,which indicated that the drug releasing amount of NPs in the culture solution was increased with extended cultured time,and that the tumor cells were induced to apoptosis distinctively.
- chitosan,
- fluorouracil,
- microemulsion,
- ionic crosslinker,
- nanoparticle
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