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Citation: CAI Zhi-Juan, XUE Si-Jia, SHEN Jie-Feng, WANG Qing-Dong. Synthesis and Inhibition of N'-Tertbutylaminocarbonyl-N-5-Substitutedphenyl-2-furylformylthiourea Derivatives Against K562 Cell Proliferation[J]. Chinese Journal of Applied Chemistry, ;2008, 25(5): 552-555. shu

Synthesis and Inhibition of N'-Tertbutylaminocarbonyl-N-5-Substitutedphenyl-2-furylformylthiourea Derivatives Against K562 Cell Proliferation

1.
College of Life and Environment Science, Shanghai Normal University, Shanghai 200234

Corresponding author: XUE Si-Jia,
Received Date: 15 June 2007
Available Online: 7 August 2007
Fund Project: 国家自然科学基金(20672073) (20672073)上海市重点学科建设项目(T0402)资助项目 (T0402)

Eightnovel N'-tertbutylaminocarbonyl-N-5-substitutedphenyl-2-furylformylthiourea derivatives were synthesized by taking active group 5-substitutedphenyl furan and tert-butylamino into the acylthiourea.Their structures were elucidated and confirmed by elemental analysis,IR,and ¹H NMR.The inhibitory rate of cellular growth of K562 cells was measured via MTT assay.The results indicated that the title compounds have some effects on the cellular growth inhibition to K562 cells of leukemia.
- synthesis,
- N'-tertbutylaminocarbonyl-N-substituted phenyl-furylformylthiourea,
- MTT assay,
- K562 cells of leukemia
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