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Citation: LI Zhuo-Ning, GAO Yuan, LIU Bo, LÜ Wei-Zhong. One-pot Synthesis of 2-Amino-7-methyl-5-oxo-4-aryl-4H,5H-pyrano-[4,3-b]pyran-3-carbonitrile under Ultrasonic Irradition[J]. Chinese Journal of Applied Chemistry, ;2008, 25(6): 744-746. shu

One-pot Synthesis of 2-Amino-7-methyl-5-oxo-4-aryl-4H,5H-pyrano-[4,3-b]pyran-3-carbonitrile under Ultrasonic Irradition

1.
College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen 518060

Corresponding author: GAO Yuan,
Received Date: 15 June 2007
Available Online: 30 August 2007
Fund Project: 广东省自然科学基金资助项目(06028565) (06028565)

A series of 2-amino-7-methyl-5-oxo-4-aryl-4H,5H-pyrano[4,3-b]pyran-3-carbonitriles were first synthesized by the reaction of each of the aromatic aldehydes with malononitrile and 4-hydroxyl-6-methyl-2-pyranone in acetic anhydride under ultrasonic irradiation.The yields were in the range of 72%~83%.The structures of the products were confirmed by IR,¹H NMR and elemental analysis.The structure of 4e was determined by X-ray analysis.The crystal was monoclinic with space group C2/c,a=2.149 17(7) nm,b=0.824 98(2) nm,c=1.791 37(6) nm,α=90°,β=112.104(2)°,γ=90°,M_r=314.72,V=2.942 54(16) nm³,Z=8,D_c=1.421 kg/m³,F(000)=1 296,R=0.049 5,wR=0.087 8.
- aromatic aldehyde,
- malononitrile,
- hydroxyl-methyl-pyranone,
- ultrasonic irradiation
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