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Citation: SUN Li-Ping, CHEN Xiao, DU Yu-Min. Synthesis,Characterization of Quaternized Carboxymethyl Chitosan and its Effect on HeLa Cells[J]. Chinese Journal of Applied Chemistry, ;2008, 25(6): 734-737. shu

Synthesis,Characterization of Quaternized Carboxymethyl Chitosan and its Effect on HeLa Cells

1.
a School of Environmental Science and Technology, Zhejiang Forestry College, Lin'an 311300;
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b College of Biology and Environmental Science, Zhejiang University of Technology, Hangzhou;
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c College of Resources and Environmental Science, Wuhan University, Wuhan

Corresponding author: SUN Li-Ping,
Received Date: 7 July 2007
Available Online: 1 November 2007

A new approach to preparation of chemically modified carboxymethyl chitosan (CM) derivatives was reported,where CM was prepared from chitosan with chloroactic acid as the carboxymethyl reagent first,and then N-quaternary ammonium group was introduced by the reaction of CM with 2,3-epoxypropyl trimethylammonium.The degree of substitution (DS) of carboxymethyl group was 0.73 and the DS of the quaternization group was 0.59.The mass-averaged molecular weight of CMQ was 1.1×10⁴.The structures of the derivatives were characterized by FT-IR,XRD and ¹³C NMR.The effect of the CMQ on the human cervical carcinoma HeLa cells showed that CMQ can inhibit the proliferation and induce the apoptosis of HeLa cells.
- quaternized carboxymethyl chitosan,
- structure characterization,
- HeLa cells
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