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Citation: ZHAO Xiao-Hui, NIU Wei-Fen. Determination of Dipyridamole with Eosin Y by a Resonance Light-Scattering Method[J]. Chinese Journal of Applied Chemistry, ;2008, 25(6): 693-696. shu

Determination of Dipyridamole with Eosin Y by a Resonance Light-Scattering Method

ZHAO Xiao-Hui ^, ,
NIU Wei-Fen

1.
Department of Chemistry and Environmental Science, Yangtze Normal University, Fuling 408003

Corresponding author: ZHAO Xiao-Hui,
Received Date: 26 June 2007
Available Online: 23 September 2007
Fund Project: 教育部春晖计划(渝教外:[2005]7-24) (渝教外:[2005]7-24)

In pH=1.98 buffer solution,dipyridamole associates with eosine Y and produces a greatly enhanced resonance light scattering (RLS) signals at 315 nm.It was found that the enhanced RLS intensity (ΔI_RLS) at 315 nm is proportional to the concentration of dipyridamole,and thus a new method for determining trace dipyridamole has been established accordingly.This method has an advantage of simplicity in experi-mental operation and conditon.The determination limit of dipyridamole is 16.1 nmol/L when the concentrations of eosine Y is 3.0×10^-5 mol/L.Simultaneously this method has been successfully applied to the actual samples,and the relatively standard deviation between 1.3% 2.5%,the recovery rate of actual sample is about (99.2±3.3)%~(102.0±1.7)%,indicating that this analysis method has the good determination accuracy and the reliability.
- dipyridamole,
- Eosin Y,
- Resonance Light Scattering
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