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Citation: WANG Qing-Dong, XUE Si-Jia, BIAN Wang-Dong, SHEN Jie-Feng, CAI Zhi-Juan. Synthesis and Bioactivity of Amide and Hydrazide Derivatives of N-(5-(2-Chlorophenyl) furan-2-formyl) glycine[J]. Chinese Journal of Applied Chemistry, ;2008, 25(6): 647-650. shu

Synthesis and Bioactivity of Amide and Hydrazide Derivatives of N-(5-(2-Chlorophenyl) furan-2-formyl) glycine

1.
a College of Life and Environment Science, Shanghai Normal University, Shanghai 200234;
2.
b Department of Chemistry, Jiangsu Yancheng Teachers College, Yancheng

Corresponding author: XUE Si-Jia,
Received Date: 11 June 2007
Available Online: 26 August 2007
Fund Project: 国家自然科学基金(20672073) (20672073)上海市重点学科建设(T0402)资助项目 (T0402)

A mixture of glycine,sodium hydroxide and 5-(2-chlorophenyl) furan-2-carbonyl chloride in a water-petroleum ether solution containing phase transfer catalyst N(CH₃)₄ Br was refluxed,and sodium N-(5-(2-chlorophenyl) furan-2-formyl) glycine was prepared.After acidification of the sodium salt,N-(5-(2-chloro-phenyl) furan-2-formyl) glycine was obtained.With N,N'-dicyclohexylcarbodiimide (DCC) as dehydration agent,amine or hydrazide derivatives of N-(5-(2-chlorophenyl) furan-2-formyl)-glycine were prepared from the reaction of the sodium salt with substituted anilines or substituted benzohydrazides respectively in DMF.The structures of all the target compounds were confirmed by IR,¹H NMR,MS,and elemental analysis.MTT assay showed that most of the target compounds possessed certain inhibition activity against K562 Cells at 1×10^-4 g/mL in vitro.
- glycine,
- (chlorophenyl) furan-carboxylic acid,
- amide,
- hydrazide,
- derivative,
- synthesis,
- K562 cell,
- MTT assay
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