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Citation: WEI Shao-Hua, LU Shan, JI Chun, LIN Yun, ZHOU Jia-Hong, LU Tian-Hong, SHEN Jian. Interaction Between p-HPcZn and CT DNA[J]. Chinese Journal of Applied Chemistry, ;2008, 25(7): 763-767. shu

Interaction Between p-HPcZn and CT DNA

WEI Shao-Hua ^a,b,, ,
LU Shan ^a,b ,
JI Chun ^a,b ,
LIN Yun ^a,b ,
ZHOU Jia-Hong ^b ,
LU Tian-Hong ^a ,
SHEN Jian ^a,b

1.
a School of Chemistry and Environmental Science, Nanjing Normal University, Nianjing 210097;
2.
b Jiangsu Engineering Research Center for Bio-medical Function Materials, Nanjing

Corresponding author: WEI Shao-Hua,
Received Date: 18 July 2007
Available Online: 28 November 2007
Fund Project: 国家自然科学基金(20673058) (20673058)江苏省自然科学基金(BK2006216) (BK2006216)江苏省高校自然科学基金(06KJB150053)资助项目 (06KJB150053)

Based on the photosensitive properties of tetra-substituted zinc phthalocyanine (p-HPcZn),the interaction of p-HPcZn with calf thymus DNA (CT DNA) was investigated by UV-Vis and fluorescence spectroscopies.It was found that p-HPcZn could insert into the double-helix of DNA.In addition,the result of CT-DNA photodamage experiments suggests that the photodamage ability of p-HPcZn is higher than that of hematoporphyrin in the presence or absence of oxygen.
- phthalocyanine,
- CT DNA,
- interaction,
- photodamage
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